CRH and alcohol dependence: The above evidence suggests that the CRF system may be implicated in stress-induced relapse to alcohol drinking and that CRF antagonists may have therapeutic potential in alcohol dependence, particularly for people with genetic variants in the CRHR1 gene that exacerbate a stress-induced susceptibility to alcohol dependence and relapse (Clinicaltrials.gov NCT01187511, 2010, Clinicaltrials.gov NCT01227980, 2011).