It also is interesting to note that low BDNF levels in the CeA and MeA mediate anxiety-like behaviors, and the anxiety-reducing (i.e., anxiolytic) effects of alcohol may be associated with an increase in BDNF signaling (Moonat et al. 2011; Pandey et al. 2006, 2008b). The gene discussed is BDNF; the disease is Anxiety.