HCRT and substance dependence: Finally, other stress-responsive systems (e.g., adrenergic, Substance P, and orexin/hypocretin systems) have been shown to influence alcohol consumption (Ciccocioppo et al. 2009; Heilig et al. 2010; Sinha et al. 2011), but their role in mediating excessive drinking associated with dependence has not been specifically examined.