FOS and anxiety disorder: In this study, in order to further define the anxiolytic functions of GP-EX, the neuropharmacological effects of GP-EX on chronic EF stress-induced anxiety disorders were investigated by examining the behavioral evaluation, using the elevated plus-maze and marble burying tests, and determining the influences on the levels of dopamine and serotonin in the brain, the serum levels of corticosterone, and the expression of c-Fos in the PVN, using a mouse animal model system.