To establish whether there was a link between resistance to Akt inhibitors and SGK1 expression, we first compared the GI50 values mediated by the Akt inhibitor AZD5363 (that does not significantly inhibit SGK1) [21] with relative SGK1 mRNA levels in 21 breast cancer cell lines (Figure 1A). The gene discussed is AKT1; the disease is breast carcinoma.