PRRT2 and hypertensive disorder: The relation between PKC and HTN could also involve changes in the vascular endothelium, ECM and MMPs-mediated vascular remodeling, oxidative stress and free radicals, renal hemodynamics and renin-angioensin system, neuronal changes and sympathetic hyperactivity, vascular inflammation and potential interactions with inflammatory cytokines, and other metabolic factors (Figure 3).