Understanding the role of PKC as a major regulator of VSM function, the PKC isoforms, their protein substrates and subcellular distribution, and their interaction with other factors such as ROS, MMPs and cytokines would provide important information regarding the benefits of determining PKC activity in the diagnosis of VSM hyperactivity disorders and the potential usefulness of PKC inhibitors in the management of vascular disease such as HTN. Here, PRRT2 is linked to hypertensive disorder.