FOXO3 and idiopathic pulmonary fibrosis: Furthermore, caspase-3/7 activity was significantly increased in IPF fibroblasts in which FoxO3a was over-expressed, while caspase-3/7 activity was only marginally increased when cav-1 was knocked-down in IPF fibroblasts over-expressing FoxO3a (Fig. 6D middle panel).