Triple-negative (basal like) sub-type, defined as tumors lacking estrogen (ER), progesterone (PR), and HER2 expression, accounts for 10%–17% of all breast carcinomas [9], shows remarkably high proliferation [10–12] and aggressive clinical behavior [13–15] and has a poor prognosis [2,16]. This evidence concerns the gene ESR1 and breast carcinoma.