EZR and lymphoma: In studies with a murine T lymphoma cell line and with naïve human T cells, overexpression of the phosphomimetic, constitutively active mutant ezrin T567D [but not of wild type (WT) ezrin] has been reported to increase the size of the uropod and enhance chemokine-induced chemotaxis (Lee et al., 2004; Li et al., 2007).