Leptin therapy has been found to reverse hyperglycemia and to prevent mortality in several rodent models of type 1 diabetes (Chinookoswong et al., 1999; Yu et al., 2008; Fujikawa et al., 2010; Wang et al., 2010b,c; Denroche et al., 2011). The gene discussed is LEP; the disease is Hyperglycemia.