APC and Familial prostate cancer: For example, it has been found that promoter hypermethylation of the APC (adenomatous polyposis coli) gene could increase β-catenin levels and lead to the activation of growth-promoting genes in colon and gastrointestinal cancer [1] and promoter hypomethylation of Wnt5a could increase this gene's transcriptional level to promote the aggressiveness of prostate cancer [2].