Indeed, AIF expression is affected by reduced BNIP3 expression mediated by microRNA 145 in prostate cancer cells.41 Nevertheless, this unique BNIP3 repressor function for DR5 gene alters TRAIL-induced apoptosis in glioma cells and could be an important mechanism for TRAIL resistance in GBM tumors. This evidence concerns the gene TNFSF10 and central nervous system cancer.