Nuclear BNIP3 has been detected in GBMs,28 lung,30 and breast tumors.31, 32 DR5 expression has been observed to be altered in GBM tumors, and high expression for DR5 is associated with better survival in GBM patients.33, 34 As both nuclear localization of BNIP3 and DR5 expression showed variable patterns in GBM tumors, we asked whether nuclear BNIP3 correlated with levels of DR5 expression in GBM tumors. The gene discussed is BNIP3; the disease is glioblastoma.