Accordingly, the hyperinsulinemia-stimulated CAT-dependent uptake of ADMA and SDMA into the cells, probably within the liver and the kidney (both referred to as a “sink” for circulating ADMA [50]) – might hypothetically be counteracted – for ADMA but not SDMA – by the hyperglycemia-induced depression of DDAH activity [48]. Here, DDAH2 is linked to Hyperinsulinemia.