Regarding to TGFBR1 and TGFBR2 genes, in contrast with a recent paper showing a missense mutation in TGFBR2 gene in a patient with BAV and aortic aneurysm [14], our findings support the studies suggesting that mutations in these genes are rarely identified in patients with familial BAV [15,16]. This evidence concerns the gene TGFBR1 and aortic aneurysm.