Baseline (enrolment) iohexol GFR and cystatin C GFR (measured 48 h prior to AKI according to AKIN criteria) displayed similar ability to predict AKI as judged by AUROC values of 0.73 (0.54–0.93), (cut-off <55 mL/min/1.73 m2) P = 0.02 and 0.71 (0.5–0.92), (cut-off <58 mL/min/1.73 m2), P = 0.05 respectively. This evidence concerns the gene CST3 and acute kidney injury.