In this study, HRP2 and pan pLDH-based immunochromatographic cassette assay was used for the first time to evaluate the role of these tests in post-treatment monitoring, according to WHO protocol for the assessment and monitoring of anti-malarial drug efficacy for the treatment of uncomplicated falciparum malaria under field conditions for up to 28 days’ follow up [2,14]. Here, HDGFL2 is linked to Plasmodium falciparum malaria.