β2-M showsan increase in parallel with the development ofCRF, leading to a decrease renal disease, the serumlevel of β2-M is between 20-50 mg/l (8).The normal level of this protein in the serumof healthy people is within 0-2.4 mg/l, and inthe saliva of healthy people it is within 0-0.38mg/l (9). The gene discussed is B2M; the disease is kidney disorder.