FTO and obesity due to melanocortin 4 receptor deficiency: The relationship between FTO genotype and T2D may also be dependent on ancestry; in whites, the risk-conferring rs9939609 A allele in FTO for obesity is also related to increased risk of T2D, whereas the risk-conferring rs1421085 C allele for obesity in African Americans may protect against T2D [44]; indeed, the risk association appears to be similar to whites in Asians [45].