In a genome-wide appraisal of CNVs, three copy-number variants overlapping the PARK2, GYPA, and SGCZ genes were associated with BMI, obesity, and obesity-related traits in the Genetic Epidemiology Network of Arteriopathy (GENOA) and Hypertension Genetic Epidemiology Network (HyperGEN) African American cohorts [60]. This evidence concerns the gene PRKN and obesity due to melanocortin 4 receptor deficiency.