NFE2L2 and cancer: In addition, analyses of tumor tissue from a variety of cancers, including lung, display overexpression of the phase II antioxidant enzymes regulated by NRF2, such as glutathione-S-transferase (GST) and NADP(H): quinone oxidoreductase 1 (NQO1), which are both known to facilitate the elimination of reactive, oxidized metabolites [30, 36].