NFE2L2 and neoplasm: Multidrug resistance protein 3 (MDR3), which has been linked to drug resistance in NSCLC, is also known to be directly induced by NRF2 in both NSCLC tumor tissue and immortalized ATCC cell lines (DU-145 prostate; H1666, H1650, and A549 (AC); H358-unspecified NSCLC) [53].