However, the levels of MDR3 in these cell lines failed to superinduce when treated with 4-hydroxy-2-nonenal, which was shown to enhance the nuclear translocation of NRF2 in the human bronchial epithelial cell line 1 (HBE1) and in a NSCLC cell line H358 (bronchoalveolar carcinoma), which lack the KEAP1 mutation [59]. This evidence concerns the gene KEAP1 and non-small cell lung carcinoma.