NFE2L2 and lung neoplasm: Nrf2 −/− and Nrf2 +/+ mice were bred to the K-RasG12D mice (B6/129/SJL background strain) in lung tumorigenesis studies which demonstrated that the Nrf2 −/− mouse had a significant reduction in K-RasG12D-initiated lung tumors compared to WT mice [77].