Using a mouse model of experimental autoimmune encephalomyelitis, Solomon et al. [16] reported that CD4+Nrp1+ T cells suppressed effector cell proliferation more efficiently than CD4+CD25+ T cells, and CD4+CD25−Nrp1+ T cells exhibited similar suppressive function as CD4+CD25+Nrp1+ T cells in preventing disease progression. This evidence concerns the gene CD4 and experimental autoimmune encephalomyelitis.