NFKB1 and posterior cortical atrophy: Although activation of NF-κB signaling in PCa cells contributes to osteoclastogenesis in vitro by regulating osteoclastogenic genes (Fig. 1, 2 and 3), when NF-κB was activated in the LNCaP cells in the bone microenvironment, they formed typical osteoblastic/osteoclastic mixed lesions (Fig. 6).