In order to determine whether activation of NF-κB signaling in PCa cells influences osteoclastogenesis in bone marrow, the monocyte/macrophage lineage progenitors from primary bone marrow cells were treated with conditioned medium from NF-κB activated/inactivated PCa cells, and monitored for osteoclast differentiation. The gene discussed is NFKB1; the disease is posterior cortical atrophy.