CACNA1A and migraine disorder: Familial Hemiplegic Migraine type 1 (FHM-1) is a rare monogenic subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene [1] that encodes the α1 subunit of neuronal voltage-gated CaV2.1(voltage-gated calcium channel type 2.1) calcium channels [2].