Because fibroblast transdifferentiation to myofibroblast, which produces main ECM components, takes the important part in the fibrosis in SSc, and affected by the signal pathway of PDGF and PDGFR, the suppression of the pathway through introducing PDGFR-α siRNA for the gene silencing and then blocking PDGFR-α mRNA and protein expression may be to become a viable approach for the treatment. Here, PDGFRB is linked to systemic sclerosis.