We tabulated all the lineages that co-occurred with each mutation (e.g. BRAF::Melanoma, BRAF::Colon, etc), and for each drug how many of each pair occurred in sensitive vs resistant lines (e.g. BRAF::Melanoma in sensitive lines = 14; BRAF::Melanoma in resistant lines = 0), and compared that, respectively, with the chance random distribution between sensitive and resistant, at P< = 0.05. Here, BRAF is linked to melanoma.