CXCL12 and Familial prostate cancer: For example, CXCL14 derived from CAFs in prostate cancer and SDF1/CXCL12 derived from CAFs in breast cancer called up macrophages, endothelial cells derived from bone marrow source, M2 mononuclear cells to the tumor tissue respectively, which assisted the tumor formation new blood and lymph vessels [45], [46].