The replicative studies of this candidate gene among a couple of Indian populations also showed strong association of TCF7L2 with T2DM but given enormous ethnic, cultural, geographic and genetic heterogeneity, large population size and relatively high prevalence of diabetes, very small and insignificant number/proportion of Indian populations were hitherto studied [13]–[17]. Here, TCF7L2 is linked to type 2 diabetes mellitus.