In somewhat a concurrent pattern, the three SNPs of TCF7L2, which are located on the chromosome 10q25.3, show strong LD and the logistic regression analysis based on haplotype frequency suggest that haplotype 222 which carries all the three risk alleles of the SNPs (rs7903146, rs11196205 and rs12255372) is most significantly associated with T2DM risk as compared to the others with either one or two of the risk alleles. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.