ADRB3 and chronic granulomatous disease: [17], study subjects were grouped according to different risk levels on the basis of the different gene polymorphisms. From this analysis, we found that development of CGD involves complex genetic interactions among the hormonal and hepatocanalicular transporter genetic variants. As our results from CART analyses consistently suggested that ESR1IVS1-397TT, ABCG8GC+CC, ESR1IVS1-351GG and ADRB3 TC+CC polymorphisms are the most important single susceptibility factor for CGD development.