In hepatocanalicular transporter pathway ABCG8 D19H and SLCO1B1 Exon4 C>A conferred increased risk for CGD At haplotypes level, we found that the gallstones subjects who carry ESR1 haplotypes IVS1-397T, IVS1-351G, Ex4-122C and SLCO1B1 haplotypes Exon4A, Ex6+40T conferred increased risk for gallstones. The gene discussed is ABCG8; the disease is gallstones.