Excision repair complementing-1 (ERCC-1) and topoisomerase 1 (TOPO-1) are important biomarkers that predict tumor responses to oxaliplatin and CPT-11, respectively, and the 2 remaining genes (vascular endothelial growth factor VEGF and epidermal growth factor receptor EGFR) are target factors for molecular targeted agents. This evidence concerns the gene EGFR and neoplasm.