CD4 and HIV-1 infection: In the majority of the EC population, the spontaneous control of HIV-1 infection is associated with higher levels of CD4+ T cells (average of 750 cells/ml) than viremic and therapy-treated HIV+ individuals, and slightly lower than uninfected subjects (Hunt et al., 2008; Hatano et al., 2009; Okulicz et al., 2009; Sedaghat et al., 2009; Kamya et al., 2011b).