Similarly, polymorphisms in the genes encoding other autophagy-related proteins, including Atg2a, Atg4a, Atg4d, Immunity-related GTPase M (IRGM), and ULK-1, have also been associated with Crohn’s disease (Craddock et al., 2010; Henckaerts et al., 2011; Brinar et al., 2012). The gene discussed is IRGM; the disease is Crohn disease.