Based on the above research, one speculative view of the mechanisms behind the cognitive symptoms of CFS is that altered CBF activation and regulation are exacerbated by a stressor, such as orthostasis or a difficult mental task, that results in the decreased ability to readily process information, which is then perceived as fatiguing and experienced as “brain fog.” Thus, future research will study if interventions that modify CBF affect the cognitive symptoms of CFS. This evidence concerns the gene CEBPZ and myalgic encephalomeyelitis/chronic fatigue syndrome.