LGALS3 and Increased total eosinophil count: In addition, we have previously shown that Gal-3-/- mice exposed to chronic allergen (OVA) challenge have attenuated airway eosinophilia and exhibit less severe remodeling of the airways, i.e., reduced mucus secretion, sub-epithelial fibrosis, smooth muscle thickness, and peribronchial angiogenesis, compared to WT counterparts (Ge et al., 2010).