For example, the NE alpha-1 antagonist prazosin has been reported to be an effective treatment for PTSD (Berger et al., 2009), and the alpha-2 agonist guanfacine is used as an alternative to psychostimulant treatment for ADHD (Bidwell et al., 2011). The gene discussed is PSMA2; the disease is attention deficit-hyperactivity disorder.