SREBP1, a cholesterol biosynthesis regulator, was significantly upregulated in pluripotent SI-187 cells compared to one control and approached significance to the second control line; a finding consistent with overt cholesterol biosynthesis disruption in HD models (Valenza et al., 2007a,b), patients (Markianos et al., 2008) and undifferentiated HD iPSC lines (Castiglioni et al., 2012). The gene discussed is SREBF1; the disease is Huntington disease.