Other genetic factors potentially involved in the pathogenesis of NAFLD and its progression include HNF4A, a type 2 diabetes-associated gene which is important in lipid oxidations and various genetic variants of CYP4F2 which plays a role in predicting the response of individuals with NAFLD to the currently available therapies [37]. This evidence concerns the gene HNF4A and metabolic dysfunction-associated steatotic liver disease.