Important antiviral factors and pathways, such as the retinoic acid-inducible gene I protein/DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (RIG-I/DDX58), Toll-like receptors (TLRs), mannose-binding lectin (encoded by MBL2), and dendritic cell−specific intercellular adhesion molecule-3−grabbing non-integrin (DC-SIGN, also known as CD209) play a role in viral sensing, control, pathogenesis, and outcome of viral infections (Thompson and Iwasaki 2008; Nakhaei et al. 2009; Faure and Rabourdin-Combe 2011; Frakking et al. 2011; Clingan et al. 2012). This evidence concerns the gene RIGI and viral infectious disease.