CDH1 and carcinoma: The disruption of junctional proteins, including E-cadherin, is required for cancer cell movement and thus is a prominent feature in most human carcinomas, leading to an invasive phenotype and poor prognosis.45 Deregulation of N-cadherin has also been implicated in cancer metastasis, promoting motility in human breast cancer cells regardless of their E-cadherin expression.49,50