SNAI2 and cancer: EMT in both the NC and cancer is triggered by various signaling pathways including BMP, Wnt, and signals from the ECM.4,8 One of the hallmark targets of these signaling pathways are the Snail family of transcription factors including Snail1 and Snail2 (also known as Slug), which are known to have an important role in both NC specification and EMT as well as in cancer progression (Figures 1 and 4).