As shown in Table 1, there were no significant differences in disease duration [21.7 ± 8.4 years (mean ± SD) vs. 16.7 ± 6.6 years], serum CRP levels (1.74 ± 2.10 mg/dl vs. 1.23 ± 1.18 mg/dl), DAS28 (DAS28-CRP with 3 variables) (4.04 ± 0.74 vs. 4.40 ± 0.85), Steinbrocker’s stages on X-ray and Steinbrocker’s functional classes between RA patients with TNF blockers and those without TNF inhibitors. This evidence concerns the gene TNF and rheumatoid arthritis.