Virus-mediated cell signalling may represent a potential therapeutic target to treat early HIV-1 infection (reviewed in [37]) and in fact, HIV-1 Env-fusogenic activity appears to be both Ca2+[38] and phosphatidylinositol (4,5)-bisphosphate (PIP2) dependent [10,22,24,36]. This evidence concerns the gene ERVW-1 and HIV-1 infection.