Interestingly, the observation that the C-terminal region of SLA/LP spanning residues 452–465 (sequence NRLDRCLKAVRKER), which was identified as the optimal CD4+ T cell epitope, overlaps with the SLA/LP sequence that is recognized by antibodies of patients with AIH suggests that the C-terminal region of SLA/LP is not only targeted by humoral, but also by cellular immune responses[4,15]. The gene discussed is SLA; the disease is autoimmune hepatitis.