Indeed, intrahepatic CD4+ T cells recognize self-antigens in the context of the alleles HLA-DRB1*03:01 and HLA-DRB1*0401, which represent the principal AIH susceptibility alleles among Europeans and Americans, and in the context of alleles HLA-DRB1*04:05 and HLA-DRB1*04:04, which are instead linked to AIH susceptibility in Japan, Argentina and Mexico[12,13]. This evidence concerns the gene HLA-DRB1 and autoimmune hepatitis.