A recent meta-analysis, which included 3,972 essential tremor (ET) patients and 20,714 controls for the LINGO1 rs9652490 polymorphism, and 2,076 ET patients and 18,792 controls for the rs11856808 polymorphism, concluded that the rs11856808 polymorphism was related with increased risk for both total and familial ET, whereas the rs9652490 polymorphism was related with increased risk for familial ET [21]. This evidence concerns the gene LINGO1 and essential tremor.