Regardless of whether TRPV1 receptor positive V1 neurons are indeed involved in migraine pathophysiology or not, they have been associated with other craniofacial pain syndromes such as dental pain where an upregulation of TRPV1 expression in rat trigeminal ganglia was observed in a model of lipopolysaccharide-induced pulpitis [32]. Here, TRPV1 is linked to pulpitis.