Using segments of internal mammary arteries obtained from adults with severe coronary artery disease (CAD), we showed [53] that the presence of obesity was associated with a higher contractile response to Ang II, after matching for age, sex, glucose and insulin plasma levels, homeostatic model assessment (HOMA) index, lipid profile, tobacco and alcohol consumption, physical activity, and arterial blood pressure. The gene discussed is AGT; the disease is coronary artery disorder.