INS and Insulin resistance: In humans Ang II produced by mature adipocytes appears to inhibit the differentiation of adipocyte precursors, thus decreasing the percentage of small insulin-sensitive adipocytes and promoting the presence of large adipocytes [56–58], which decrease insulin sensitivity and produce ectopic deposition of lipids that promotes the development not only of hypertension, but also of insulin resistance and type 2 diabetes [62].