After infection, mice immunized with rLiHyp1 plus saponin, when compared to control groups, displayed significant reductions of the number of parasites in all evaluated organs (liver, spleen, BM, and dLN), which correlated a specific rLiHyp1- and SLA-dependent IFN-γ production in the spleen, one of the main cytokines implicated in the acquired immunity against infection with Leishmania[22], [23], [24]. The gene discussed is SLA; the disease is infection.