MBL2 and infection: We confirmed that early endosomal acidification is important for EBOV infection as evidenced by the fact that the lysosomotropic agent bafilomycin A1, a specific and potent inhibitor of vacuolar H+ ATPase in early endosomes [55], reduced infection but to a significantly lesser extent in the presence of MBL suggesting that MBL-mediated endocytosis bypasses early endosomes (Figure S5).