MACC1 and nasopharyngeal carcinoma: To further investigate the underlying mechanism of MACC1 in tumorigenesis of NPC, we down-regulated MACC1 expression in CNE2 cells transfected with MACC1 siRNA for 48 hours , both mRNA and protein levels of β-catenin and Met was significantly suppressed compared with the control group by real-time PCR and western blot analysis, respectively (Figure 4).