Additionally, H&E stained vessels showed no change in vessel morphology (Figure 6C) and loss of TNFα did not change vessel response to L-NAME at days three and seven during infection; arteriole response to application of L-NAME at day zero in TNFα deficient mice was similar to wild-type mice, and a significant decrease in response is seen at day three p.i., which returns to normal levels by day seven p.i. (Figure 7D). The gene discussed is TNF; the disease is infection.