Analysis of the allelic distribution among patients according to their asthma severity also indicated nominally significant associations of allele A of IL-4Rα A1199>C, allele T of IL-4Rα T1570>C and allele A of TNFα TNFα C-863>A with asthma severity (p = 0.033, p = 0.018 and p = 0.047, respectively). The gene discussed is TNF; the disease is asthma.