BECN1 and ovarian carcinoma: Meanwhile, X-tile software version 3.6.1 (Yale University School of Medicine, New Haven, CT), a reliable promising program to analyze optimal cutpoint of biomarkers [28], was introduced to determine the cutpoint of Beclin 1 and Bcl-xL IHC expressions in our ovarian carcinoma cohort and thus, the clinicopathologic/prognostic value of Beclin 1 expression and its association with Bcl-xL in ovarian carcinomas were analyzed.