Tumor tissues were only available in 14 LS CRC patients, one (7.14%) patient carried a somatic mutation in hMLH1 and three (21.43%) patients carried a somatic mutation in hMSH2. In total, four (28.57%) patients exhibited somatic mutations in hMLH1/hMSH2 gene. This evidence concerns the gene MLH1 and colorectal carcinoma.