In our previous meta-analysis based on the germline mutations of hMLH1 and hMSH2 genes (paper accepted, 10.1371/journal.pone.0051240), the pooled pathologic mutation frequency of hMLH1 was 8.72% (95%CI: 6.12%–12.29%) in sporadic CRC. Here, MSH2 is linked to colorectal carcinoma.